EV-miRNA-Mediated Intercellular Communication in the Breast Tumor Microenvironment

Cancer research has prioritized the study of tumor microenvironment (TME) as a crucial area investigation. Understanding communication between cells and various cell types within TME become focal point. Bidirectional processes these support cellular transformation, well survival, invasion, metastatic dissemination cells. Extracellular vesicles are lipid bilayer structures secreted by that emerge important mediators this cell-to-cell communication. EVs transfer their molecular cargo, including proteins nucleic acids, particularly microRNAs, which play critical roles in intercellular Tumor-derived EVs, for example, can promote angiogenesis enhance endothelial permeability delivering specific miRNAs. Moreover, adipocytes, significant component breast stroma, exhibit high EV secretory activity, then modulate metabolic processes, promoting growth, proliferation, migration Comprehensive studies investigating involvement miRNA cargo TME, underlying mechanisms driving tumoral capacities, necessary deeper understanding complex interactions. Such knowledge holds promise development novel diagnostic therapeutic strategies cancer treatment.